Publications

An aged microenvironment increases CAR T cell cytotoxicity but impairs therapeutic efficacy

Mona Kabha, Noy Rosenzweig, Akmaral Rakhymzhanova, Orna Atar, Cyrille J. Cohen and Noga Ron-Harel. bioRxiv 2025.05.04.652106; doi: https://doi.org/10.1101/2025.05.04.652106

Heme and iron toxicity in the aged spleen impairs T-cell immunity through iron deprivation

David Ezuz, Heba Ombashe, Lana Watad, Akmaral Rakhymzhanova, Satyarth Pandey, Orna Atar, Esther G. Meyron-Holtz and Noga Ron-Harel. Nature Aging. 2025; 5(11): 2247-2262.; doi: 10.1038/s43587-025-00981-4

CARMIL2 Deficiency Disrupts Activation-Induced Metabolic Reprogramming in T Cells and is partially Rescued by Glutamine Supplementation

Mona Kabha, Maya Liaks-Bohnick, Fadia Zagairy, Orna Atar, Mira Hamed, Micheal Ziv, Nada Danial-Farran, Morad Khayat, Orly Ishach, Yael Dinur-Schejter, Vered Molcho- Pesshach, Ido Somekh, Shirley Frizinsky, Efrat Bar-Ilan, Shoshanna Greenberger, NasserEddin Adeeb, Raz Somech, Polina Stepansky, Noga Ron-Harel*, Eran Cohen-Barak*. (*Co-Corresponding authors). J of Allergy and Clinical Immunology. 156(5): 1390-1400. Doi: 10.1016/j.jaci.2025.07.018.

Genetically engineering glycolysis in T cells increases their anti-tumor function

Raphaëlle Toledano Zur, Orna Atar , Tilda Barliya, Shiran Hoogi, Ifat Abramovich, Eyal Gottlieb, Noga Ron-Harel and Cyrille J. Cohen. J Immunother Cancer. 2024; 20(7): e008434; doi: 10.1136/jitc-2023-008434.

Metabolic modeling of single Th17 cells reveals regulators of autoimmunity

Allon Wagner, Chao Wang, Johannes Fessler, David DeTomaso, Julian Avila-Pacheco, James Kaminski, Sarah Zaghouani, Elena Christian, Pratiksha Thakore, Brandon Schellhaass, Elliot Akama-Garren, Kerry Pierce, Vasundhara Singh, Noga Ron-Harel, Vivian Paraskevi Douglas, Lloyd Bod, Alexandra Schnell, Daniel Puleston, Raymond A. Sobel, Marcia Haigis, Erika L. Pearce, Manoocher Soleimani, Clary Clish, Aviv Regev, Vijay K. Kuchroo and Nir Yosef. Cell, 2021, 184, 4168–4185

Nucleotide metabolism and therapies at the nexus of viral, cancer, and immunometabolism

Yarden Ariav, James H Ch’ng, Heather R. Christofk, Noga Ron-Harel* and Ayelet Erez* (*Corresponding author). Sci Adv. 2021 May 19;7(21):eabg6165.

T cell activation depends on cellular alanine

Noga Ron-Harel, Jonathan Ghergurovich, Giulia Notarangelo, Martin W LaFleur, Yoshiki Tsubosaka, Arlene H. Sharpe, Joshua D. Rabinowitz and Marcia C. Haigis. Cell Reports, 2019, 28(12), 3011-3021.e4.

Adaptation of human iSPC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming

Huan Wang, Robert P Sheehan, Adam C. Palmer, Robert A. Everley, Sarah A. Boswell, Noga Ron-Harel, Alison E. Ringel, Kristina M. Holton, Conor A. Jacobson, Alison R. Erickson, Laura Maliszewski, Marcia C. Haigis and Peter K. Sorger. Cell Systems, 2019, 8(5), 412-426.e7).

Defective respiration and one-carbon metabolism contribute to impaired naïve T cell function in aged mice

Noga Ron-Harel, Giulia Notarangelo, Jonathan Ghergurovich, Joao A. Paulo, Peter T. Sage, Daniel Santos, F. Kyle Satterstrom, Steven Gygi, Joshua D. Rabinowitz, Arlene H. Sharpe and Marcia C. Haigis. PNAS, 2018, 115(52), 13347-13352.

Maintenance of CD4 T Cell Fitness Through Regulation of Foxo1

Ryan H. Newton, Sharad Shresta, Jenna M. Sullivan, Kathleen B. Yates, Ewould B. Compeer, Noga Ron-Harel, Bruce, R. Blazar, Steven J. Besinger, W. Nicholas Haining, Michael L. Dustin, Daniel J. Campbell, Hongbo Chi, Laurence A. Turka. Nature Immunology, 2018, 19(8): 838-848.

Mitochondrial biogenesis and proteome remodeling promote one-carbon metabolism for T cell activation

Noga Ron-Harel, Daniel Santos, Jonathan Ghergurovich, Peter T. Sage, Anita Reddy, Scott B. Lovitch, Noah Dephoure, F. Kyle Satterstrom, Michal Sheffer, Jessica B. Spinelli, Steven Gygi, Joshua D. Rabinowitz, Arlene H. Sharpe and Marcia C. Haigis. Cell Metabolism, 2016 24(1): 104-117- featured article. Highlighted in the Editor’s Choice section by Science (Science, 2016, 353(6299) pp. 554).

Suppression by TFR cells leads to durable and selective inhibition of B cell effector functions

Peter T. Sage, Noga Ron-Harel, Vikram R. Juneja, et. al. Nature Immunology 2016, 17(12), 1436-1446.

Mitochondrial Metabolism in T cell activation and senescence

Noga Ron-Harel, Arlene H. Sharpe and Marcia C. Haigis. Gerontology, 2015 61(2): 131-8.

CNS-specific immunity at the choroid plexux shifts towards destructive Th2 inflammation in brain aging

Kuti Baruch*, Noga Ron-Harel*, et al (*equal contribution). PNAS. 2013 Feb 5;110(6):2264-9.

Brain homeostasis is maintained by danger signals stimulating a supportive immune response within the brain’s borders

Noga Ron-Harel, Michal Cardon, and Michal Schwartz. Brain Behav Immun. 2011 Jul;25(5):1036-43.

Thymic involution in Amyotrophic Lateral Sclerosis

Akop Seksenyan*, Noga Ron-Harel*, David Azoulay, Liora Cahalon, Michal Cardon, Patricia Rogeri, Minhee K. Ko, Miguel Weil, Shlomo Bulvik, Gidi Rechavi, Ninette Amariglio, Eli Konen, Maya Koronyo-Hamaoui, Raz Somech and Michal Schwartz. (*equal contribution). J Cell Mol Med. 2010 Oct;14(10):2470.

Dysregulation of kisspeptin and neurogenesis at adolescence link inborn immune deficits to the late onset of abnormal sensorimotor gating in congenital psychological disorders

Michal Cardon*, Noga Ron-Harel*, Hagit Cohen, Gil M. Lewitus and Michal Schwartz. (*equal contribution). Molecular Psychiatry, 2010 15(4):415-25.